i kappa b kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0306	MLN120B		IκB/IKK
	MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).		IκB/IKK
T6771	AZD3264		IκB/IKK
	AZD3264 is a new type IKK2 inhibitor.		IκB/IKK
T5540	GSK8612		IκB/IKK
	GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .		IκB/IKK
T15564	IMD-0560		IκB/IKK
	IMD-0560 is a novel inhibitor of IκB kinase β.		IκB/IKK
T5209	INH14		IκB/IKK
	INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).		IκB/IKK
T1830	BX795		IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy
	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than...		IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy
T10477	BAY-985		IκB/IKK
	BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy.		IκB/IKK
T7951	TBK1/IKKε-IN-5		IκB/IKK
	TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).		IκB/IKK
T15559	TBK1/IKKε-IN-2		IκB/IKK
	TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.		IκB/IKK
T5796	Plantainoside D	Isoplantamajoside	RAAS , PKC
	Plantainoside D (Isoplantamajoside) shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it ...		RAAS , PKC
T8705	BOT-64		IκB/IKK
	BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound		IκB/IKK
T10237	ACHP Hydrochloride	IKK-2 Inhibitor VIII	IκB/IKK
	ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.		IκB/IKK
T3094	PS-1145	IKK Inhibitor X	Apoptosis , IκB/IKK
	PS-1145 (IKK Inhibitor X) is a specific IKK inhibitor with IC50 of 88 nM.		Apoptosis , IκB/IKK
T2081	LY2409881 trihydrochloride	LY2409881	Apoptosis , IκB/IKK
	LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 and other common kinases is at least one log higher.		Apoptosis , IκB/IKK
T6141	IMD-0354	IKK2 Inhibitor V,IMD 0354	IκB/IKK
	IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.		IκB/IKK
T2118	SC-514	GK 01140	IκB/IKK , p38 MAPK , Serine Protease , CDK , Aurora Kinase
	SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.		IκB/IKK , p38 MAPK , Serine Protease , CDK , Aurora Kinase
TD0099	Malachite green oxalate		Apoptosis , Others , IκB/IKK , NF-κB
	Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.		Apoptosis , Others , IκB/IKK , NF-κB
T6176	IKK 16	IKK Inhibitor VII,IKK-16,IKK16	IκB/IKK , LRRK2
	IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.		IκB/IKK , LRRK2
T0708	Oxaprozin	Oxaprozinum,Wy21743	NF-κB , COX
	Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compound...		NF-κB , COX
T0097	MRT67307	MRT67307 HCl	IκB/IKK , Autophagy
	Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage...		IκB/IKK , Autophagy